Singleton's work has an ephemeral and theatrical quality. She works on the floor, intuitively moving around the panel or object and laying down color. Her hand-made oil and acrylic paints give varying textures to her paintings and sculptures. She collages in prints and found materials and objects to create unexpected forms and narrative shifts in her imagery.

Like Goya and Beckmann, Singleton devises fictitious narratives and subversive characters to explore the issues our contemporary society faces through fantastical roll play and metaphor. Her work embraces a punk, comic book, street art rawness. Activists, queers, witches, monsters, forgotten goddesses and gods, and other sordid characters, come face to face with oppression and villainy to play out a fantasy that flirts with future possibilities. She sees her paintings as permanent documents of our particular time period. While her paintings are saturated in rebellion and protest, they celebrate difference, the power of the underdog and resilience in the face of adversity.

Themes in Singleton's paintings identify with the LGBTQ, Feminist, activist and immigrant communities. Imagery representing “the Other” in her paintings, like solitary figures situated in hostile foreign environments emanates an outsider feeling. Akin to her Greek ancestral roots, Singleton's heroes, monstrosities, hybrid animal/humans and divine entities are metaphors for the ills and woes of our collective struggle.